Welcome to the Dudley lab at UNC Chapel Hill!
Our lab is focused on the tumor microenvironment and mechanisms of tumor neovascularization. We use transgenic tumor models, in vivo lineage tracing strategies, and freshly isolated tumor-specific endothelial cells to explore differentiation and specialization of the tumor vasculature. We are also focused on how other cell types in the tumor microenvironment, including adipocytes and inflammatory cells, contribute to the growth and formation of new tumor blood vessels. Our goals are to i) understand how different types of cells in the tumor microenvironment coalesce to form new tumor vasculature ii) determine how abnormalities in the tumor vasculature contribute to tumor progression, responses to therapy, and metastasis iii) develop new tumor microenvironment-targeted therapies that are based on a systematic understanding of tumor vascular biology.